NLRP3 Monoclonal / Unconjugated / 25N10E9

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-03948SS (View supplier product page)
Size 0.025 mg
Price $169.00
Antigen NLRP3
Clone 25N10E9
Host Mouse
Isotype IgG2b κ
Conjugate Unconjugated
Target Species Human, Mouse
Applications WB
Description The epitope that 25N10E9 binds to the NOD region of NLRP3/NALP3 has not been mapped.
About NLRP3 and Purified
NLRP3 This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Aug 2020]
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Purified Excitation and Emission Spectra