Niemann-Pick C1 Polyclonal / Unconjugated /
Niemann-Pick C1 Polyclonal / Unconjugated /
Citations:
(1)
Product Details
| Supplier | Novus Biologicals, a Bio-Techne brand | |
|---|---|---|
| Catalog #: | NBP2-26214 (View supplier product page) | |
| Size | 0.1 mg | |
| Price | $399.00 | |
| Antigen | Niemann-Pick C1 | |
| Clone | ||
| Host | Goat | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | WB, ELISA | |
| Description | Goat Niemann-Pick C1 antibody [Purified] detects Human |
About Niemann-Pick C1 and Purified
| Niemann-Pick C1 | This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009] |
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Images
![Niemann-Pick C1 Purified Novus Biologicals, a Bio-Techne brand antibody anti target:Human host:Goat isotype:IgG clone: Western Blot: Niemann-Pick C1 Antibody [NBP2-26214] - Staining of HEK293 lysate (35 ug protein in...](http://images.novusbio.com/images2/Niemann-Pick-C1-Antibody-Western-Blot-NBP2-26214-img0001.jpg)
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Western Blot: Niemann-Pick C1 Antibody [NBP2-26214] - Staining of HEK293 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. |
Citations
| PMID 19474101 | ||
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| Additional Sources |
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Reviews & Ratings
Purified Excitation and Emission Spectra
$399.00
Supplier Page
Supplier Page
