NCF4 Polyclonal / Unconjugated /

Citations: (1)
Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-61666 (View supplier product page)
Size 0.1 mg
Price $399.00
Antigen NCF4
Clone
Host Goat
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications WB, IHC, IHC-P, ELISA
Description This antibody is expected to recognise both reported isoforms (NP_000622.2 and NP_038202.1).
About NCF4 and Purified
NCF4 The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Citations
PMID 17435756
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Purified Excitation and Emission Spectra