Myogenin Monoclonal / HRP / MGN185 + F5D

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-34684H (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen Myogenin
Clone MGN185 + F5D
Host Mouse
Isotype IgG
Conjugate HRP
Target Species Feline, Human, Mouse, Porcine, Rat
Applications WB, IHC-P, IHC-Fr, IHC
Description Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Anti-myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms tumor.
About Myogenin and HRP
Myogenin Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]
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HRP Excitation and Emission Spectra