MDC1 Monoclonal / Janelia Fluor 549 / P2B11

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-12890JF549 (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen MDC1
Clone P2B11
Host Mouse
Isotype IgG1
Conjugate Janelia Fluor 549
Target Species Bovine, Human, Mouse, Non-Human Primate
Applications ICC, IF
Description Detects approx 184kDa. This antibody recognizes MDC1 at and around the N-terminus.
About MDC1 and Janelia Fluor 549
MDC1 The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Janelia Fluor 549 Janelia Fluor® 549 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 549 has an excitation peak at 549 nm and an emission peak at 571 nm.
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Janelia Fluor 549 Excitation and Emission Spectra