MBD3 Monoclonal / Biotin / 106B691

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-56534B (View supplier product page)
Size 0.1 ml
Price $429.00
Antigen MBD3
Clone 106B691
Host Mouse
Isotype IgG1 κ
Conjugate Biotin
Target Species Human, Mouse
Applications WB, IHC-P, IHC
Description The theoretical molecular weight of human MBD2 (411 amino acids) is 45 kD and human MBD3 (291 amino acids) is 33 kD. Based on sequence identity, this will detect human, mouse, and rat MBD3 (100%), and human and mouse MBD2 (93%).
About MBD3 and Biotin
MBD3 DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
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Biotin Excitation and Emission Spectra