MBD2 Polyclonal / Unconjugated /

Citations: (3)
Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-81657 (View supplier product page)
Size 0.1 ml
Price $449.00
Antigen MBD2
Clone
Host Rabbit
Isotype IgG
Conjugate Unconjugated
Target Species Human, Mouse
Applications WB, IHC, IP, IHC-P, ChIP
Description Rabbit MBD2 antibody [Purified] detects Human, Mouse
About MBD2 and Purified
MBD2 DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Citations
PMID 25453762
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Purified Excitation and Emission Spectra