MAML2 Monoclonal / Alexa Fluor 405 / MAML2/1302

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-54588AF405 (View supplier product page)
Size 100 ul
Price $519.00
Antigen MAML2
Clone MAML2/1302
Host Mouse
Isotype IgG2a
Conjugate Alexa Fluor 405
Target Species Human
Applications WB, FC, ICC/IF, IHC-P, IHC
Description Mouse MAML2 antibody [Alexa Fluor 405] detects Human
About MAML2 and Alexa Fluor 405
MAML2 The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra