FluoroFinder

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP2-39033 (View supplier product page)
	Size	0.1 ml
	Price	$519.00
	Antigen	LRP-2
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human
	Applications	IHC, IHC-P
	Description	Specificity of human LRP2 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.

	LRP-2	The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]

		Immunohistochemistry-Paraffin: LRP2 Antibody [NBP2-39033] - Staining of human kidney shows high expression.
		Immunohistochemistry-Paraffin: LRP2 Antibody [NBP2-39033] - Staining of human lymph node shows low expression as expected.
		Immunohistochemistry-Paraffin: LRP2 Antibody [NBP2-39033] - Staining in human kidney and lymph node tissues using anti-LRP2 antibody. Corresponding LRP2 RNA-seq data are presented for the same tissues.