FluoroFinder

Laminin gamma 1 Polyclonal / Unconjugated /

Citations: (1)

Product Details

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP1-87719 (View supplier product page)
	Size	0.1 ml
	Price	$519.00
	Antigen	Laminin gamma 1
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human
	Applications	WB, IHC, IHC-P
	Description	Specificity of human Laminin gamma 1 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.

About Laminin gamma 1 and Purified

	Laminin gamma 1	Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]

Images

		Immunohistochemistry-Paraffin: Laminin gamma 1 Antibody [NBP1-87719] - Staining of human kidney.
		Immunohistochemistry-Paraffin: Laminin gamma 1 Antibody [NBP1-87719] - Staining in human placenta and tonsil tissues using anti-LAMC1 antibody. Corresponding LAMC1 RNA-seq data are presented for the same tissues.
		Immunohistochemistry-Paraffin: Laminin gamma 1 Antibody [NBP1-87719] - Staining of human placenta shows high expression.
		Immunohistochemistry: Laminin gamma 1 Antibody [NBP1-87719] - Staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.
		Immunohistochemistry-Paraffin: Laminin gamma 1 Antibody [NBP1-87719] - Staining of human tonsil shows low expression as expected.
		Immunohistochemistry-Paraffin: Laminin gamma 1 Antibody [NBP1-87719] - Staining of human cerebral cortex.
		Western Blot: Laminin gamma 1 Antibody [NBP1-87719] - Analysis in human cell line BEWO.
		Immunohistochemistry-Paraffin: Laminin gamma 1 Antibody [NBP1-87719] - Staining of human cerebral cortex, kidney, placenta and tonsil using Anti-LAMC1 antibody NBP1-87719 (A) shows similar protein distribution across tissues to independent antibody NBP1-87718 (B).

Citations

	PMID 22361696
	Additional Sources

Reviews & Ratings

Submit a Review

Purified Excitation and Emission Spectra

$519.00
Supplier Page

Submit a Review