FluoroFinder

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP2-37898 (View supplier product page)
	Size	0.1 ml
	Price	$519.00
	Antigen	HSD11B2
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human
	Applications	WB, IHC, IHC-P
	Description	Specificity of human HSD11B2 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.

	HSD11B2	There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]

		Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining in human kidney and liver tissues using anti-HSD11B2 antibody. Corresponding HSD11B2 RNA-seq data are presented for the same tissues.
		Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining of human rectum.
		Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining of human kidney shows high expression.
		Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining of human kidney, liver, lymph node and rectum using Anti-HSD11B2 antibody NBP2-37898 (A) shows similar protein distribution across tissues to independent antibody NBP2-37954 (B).
		Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining of human lymph node.
		Immunohistochemistry-Paraffin: HSD11B2 Antibody [NBP2-37898] - Staining of human liver shows low expression as expected.
		Western Blot: HSD11B2 Antibody [NBP2-37898] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10 Lane 2: Human Kidney tissue