FluoroFinder

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP2-54715 (View supplier product page)
	Size	100 ul
	Price	$519.00
	Antigen	Glutamate Dehydrogenase
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human
	Applications	WB, IHC, ICC/IF, IHC-P
	Description	Specificity of human Glutamate Dehydrogenase antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.

	Glutamate Dehydrogenase	This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]

		Immunohistochemistry-Paraffin: Glutamate Dehydrogenase Antibody [NBP2-54715] - Staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.
		Immunocytochemistry/Immunofluorescence: Glutamate Dehydrogenase Antibody [NBP2-54715] - Staining of human cell line A-431 shows localization to mitochondria.
		Western Blot: Glutamate Dehydrogenase Antibody [NBP2-54715] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10 Lane 2: Human cell line RT-4 Lane 3: Human cell line U-251 MG Lane 4: Human plasma Lane 5: Human Liver tissue Lane 6: Human Tonsil tissue