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Glutamate Dehydrogenase Polyclonal / Unconjugated /

Product Details

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP2-54700 (View supplier product page)
	Size	100 ul
	Price	$519.00
	Antigen	Glutamate Dehydrogenase
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human
	Applications	IHC, IHC-P
	Description	Specificity of human Glutamate Dehydrogenase antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.

About Glutamate Dehydrogenase and Purified

	Glutamate Dehydrogenase	This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]

Images

Immunohistochemistry-Paraffin: Glutamate Dehydrogenase Antibody [NBP2-54700] - Staining of human testis shows moderate cytoplasmic positivity in cells in seminiferus ducts and Leydig cells.

Citations

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