FluoroFinder

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP1-86671 (View supplier product page)
	Size	0.1 ml
	Price	$549.00
	Antigen	FOXP2
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human, Mouse, Rat
	Applications	IHC, IHC-P, ICC/IF, WB
	Description	Specificity of human, rat FoxP2 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.

	FOXP2	This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

		Immunohistochemistry-Paraffin: FoxP2 Antibody [NBP1-86671] - Staining of human rectum shows moderate nuclear positivity in glandular cells.
		Immunohistochemistry-Paraffin: FoxP2 Antibody [NBP1-86671] - Staining of human skin shows moderate nuclear positivity in deep epidermal cells.
		Immunohistochemistry-Paraffin: FoxP2 Antibody [NBP1-86671] - Staining of human oral mucosa shows moderate nuclear positivity in squamous epithelial cells.
		Immunohistochemistry-Paraffin: FoxP2 Antibody [NBP1-86671] - Staining of human cerebral cortex shows moderate to strong nuclear positivity in neurons.
		Immunohistochemistry-Paraffin: FoxP2 Antibody [NBP1-86671] - Staining of human skeletal muscle shows no positivity in striated muscle fibers as expected.