FluoroFinder

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP1-28868 (View supplier product page)
	Size	0.1 ml
	Price	$399.00
	Antigen	ER81
	Clone	1C8B6
	Host	Mouse
	Isotype	IgG1
	Conjugate	Unconjugated
	Target Species	Human
	Applications	WB, ELISA
	Description	Specific for ETV1.

	ER81	This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]

		Western Blot: ER81 Antibody (1C8B6) [NBP1-28868] - Analysis using ETV1 mouse mAb against truncated Trx-ETV1 recombinant protein (1) and full-length ETV1 (aa1-477)-hIgGFc transfected CHO-K1 cell lysate(2).
		Western Blot: ER81 Antibody (1C8B6) [NBP1-28868] - Analysis using ETV1 mouse mAb against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY ETV1 cDNA (2).