DISABLED HOMOLOG 2 Monoclonal / Unconjugated / 1C8

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: H00001601-M06 (View supplier product page)
Size 0.1 mg
Price $519.00
Antigen DISABLED HOMOLOG 2
Clone 1C8
Host Mouse
Isotype IgG2a κ
Conjugate Unconjugated
Target Species Human
Applications WB, ELISA
Description DAB2 - disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (1C8)
About DISABLED HOMOLOG 2 and Purified
DISABLED HOMOLOG 2 This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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Purified Excitation and Emission Spectra