FluoroFinder

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP2-23549 (View supplier product page)
	Size	250 ug
	Price	$383.00
	Antigen	Complement C2
	Clone	5C3
	Host	Mouse
	Isotype	IgG2a κ
	Conjugate	Unconjugated
	Target Species	Human
	Applications	WB, ELISA, IHC
	Description	Clone 5C3 is specific for C2 from human plasma/serum. Cross-reactivity to C2 from other species has not been tested.

	Complement C2	Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

		Immunohistochemistry: Complement Component C2 Antibody (5C3) - BSA Free [NBP2-23549] - Staining of human kidney shows strong positivity in extracellular material.
		Western Blot: Complement Component C2 Antibody (5C3) - BSA Free [NBP2-23549] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 11 Lane 2: RT4 Lane 3: U-251 MG Lane 4: Human Plasma Lane 5: Liver Lane 6: Tonsil