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Bcl-10 Polyclonal / Unconjugated /

Product Details

	Supplier	Novus Biologicals, a Bio-Techne brand
	Catalog #:	NBP2-15554 (View supplier product page)
	Size	0.1 ml
	Price	$449.00
	Antigen	Bcl-10
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human, Mouse
	Applications	WB, IHC, ICC/IF, IP, IHC-P, Knockout Validated
	Description	Rabbit Bcl-10 antibody [Purified] reacts with Human, Mouse

About Bcl-10 and Purified

	Bcl-10	This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Images

		Immunohistochemistry-Paraffin: Bcl10 Antibody [NBP2-15554] - Immunohistochemical analysis of paraffin-embedded Gastric ca, using antibody at 1:500 dilution.
		Immunocytochemistry/Immunofluorescence: Bcl10 Antibody [NBP2-15554] - BCL10 antibody detects BCL10 protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 2% paraformaldehyde/culture medium at 37C for 30 min. Green: BCL10 protein stained by BCL10 antibody diluted at 1:500. Blue: Hoechst 33342 staining.
		Western Blot: Bcl10 Antibody [NBP2-15554] - BCL10 antibody detects BCL10 protein by Western blot analysis. A. 30 ug Neuro2A whole cell lysate/extract B. 30 ug GL261 whole cell lysate/extract C. 30 ug C8D30 whole cell lysate/extract12 % SDS-PAGEBCL10 antibody dilution: 1:1000.
		Western Blot: Bcl10 Antibody [NBP2-15554] - Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE gel, diluted at 1:1000.
		Immunoprecipitation: Bcl-10 Antibody [NBP2-15554] - IP samples: Raji whole cell extract A. 40 ug Raji whole cell extract B. Control with 4 ug of preimmune Rabbit IgG C. Immunoprecipitation of BCL10 protein by 4 ug BCL10 antibody 12 % SDS-PAGE The immunoprecipitated BCL10 protein was detected by BCL10 antibody diluted at 1:500. [EasyBlot anti-rabbit IgG was used as a secondary reagent].
		Knockout Validated: Bcl-10 Antibody [NBP2-15554] - Wild-type (WT) and BCL10 knockout (KO) HeLa cell extracts (30 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with BCL10 antibody. HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

Citations

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