Integrin beta 7 Monoclonal / Janelia Fluor 646 / 2G18

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB110-94147JF646 (View supplier product page)
Size 0.1 ml
Price $549.00
Antigen Integrin beta 7
Clone 2G18
Host Rat
Isotype IgG2
Conjugate Janelia Fluor 646
Target Species Mouse
Applications FC, IHC, IHC-P
Description This was selected for its ability to detect mouse CD45 positive leukocytes in IHC.
About Integrin beta 7 and Janelia Fluor 646
Integrin beta 7 This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Janelia Fluor 646 Janelia Fluor® 646 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 646 has an excitation peak at 646 nm and an emission peak at 664 nm.
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Janelia Fluor 646 Excitation and Emission Spectra