CD137L Monoclonal / Janelia Fluor 549 / RM0067-3H19

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-21514JF549 (View supplier product page)
Size 0.1 ml
Price $549.00
Antigen CD137L
Clone RM0067-3H19
Host Rat
Isotype IgG2
Conjugate Janelia Fluor 549
Target Species Mouse
Applications FC
Description This was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse recombinant 4-1BB Ligand Extracellular domain.
About CD137L and Janelia Fluor 549
CD137L The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
Janelia Fluor 549 Janelia Fluor® 549 was developed at the Janelia Campus of the Howard Hughes Medical Institute but is commercialized by other vendors. The Janelia Fluor®s family is unique in that the fluorophores are cell-permeable and are available in photoactivatable forms. These fluorophores were developed for super-resolution microscopy (STED, PALM and STORM) and live-cell microscopy in the HaloTag and SNAP-tag versions. Janelia Fluor® 549 has an excitation peak at 549 nm and an emission peak at 571 nm.
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Janelia Fluor 549 Excitation and Emission Spectra