IL-10 R alpha Monoclonal / HRP / RM0101-9E12

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-22459H (View supplier product page)
Size 0.1 ml
Price $549.00
Antigen IL-10 R alpha
Clone RM0101-9E12
Host Armenian Hamster
Isotype IgG2
Conjugate HRP
Target Species Mouse
Applications WB, IHC, IHC-P
Description This was produced from a hybridoma (mouse myeloma fused with spleen cells from a hamster immunized with mouse recombinant protein of extracellular domain of IL-10R alpha.
About IL-10 R alpha and HRP
IL-10 R alpha The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
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HRP Excitation and Emission Spectra