Frizzled-6 Monoclonal / Alexa Fluor 647 / RM0237-6H38

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-12318AF647 (View supplier product page)
Size 100 μl
Price $479.00
Antigen Frizzled-6
Clone RM0237-6H38
Host Rat
Isotype IgG2
Conjugate Alexa Fluor 647
Target Species Mouse
Applications WB
Description Rat Frizzled-6 antibody reacts with Mouse [Alexa Fluor 647]
About Frizzled-6 and Alexa Fluor 647
Frizzled-6 This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
Alexa Fluor 647 Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye.
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Alexa Fluor 647 Excitation and Emission Spectra