MSR1 Monoclonal / Alexa Fluor 647 / 351615
MSR1 Monoclonal / Alexa Fluor 647 / 351615
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | FAB2708R-100UG (View supplier product page) | |
| Size | 100 μg | |
| Price | $419.00 | |
| Antigen | MSR1 | |
| Clone | 351615 | |
| Host | Mouse | |
| Isotype | IgG2b | |
| Conjugate | Alexa Fluor 647 | |
| Target Species | Human | |
| Applications | FC | |
| Description | Human SR-AI/MSR Alexa Fluor® 647-conjugated Antibody |
About MSR1 and Alexa Fluor 647
| MSR1 | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| Alexa Fluor 647 | Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye. |
Images
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Detection of SR-AI/MSR in Human M2 Macrophages by Flow Cytometry. Human M2 macrophages were stained with Mouse Anti-Human CD163 PE-conjugated Monoclonal Antibody (Catalog # FAB1607P) and either (A) Mouse Anti-Human SR-AI/MSR Alexa Fluor® 647-conjugated Monoclonal Antibody (Catalog # FAB2708R) or (B) Mouse IgG2B Alexa Fluor® 647-conjugated Isotype Control (Catalog # IC0041R). View our protocol for Staining Membrane-associated Proteins. |
Citations
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Reviews & Ratings
Alexa Fluor 647 Excitation and Emission Spectra
$419.00
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