Nectin-4 Polyclonal / Unconjugated /
Nectin-4 Polyclonal / Unconjugated /
Citations:
(9)
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | AF2659 (View supplier product page) | |
| Size | 100 μg | |
| Price | $489.00 | |
| Antigen | Nectin-4 | |
| Clone | ||
| Host | Goat | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Canine, Cynomolgus macaque, Hamster, Human, Monkey, Mouse | |
| Applications | WB, FC, IHC, CyTOF, IHC-P, Block/Neutralize, ICC, Functional | |
| Description | Human Nectin-4 Antibody |
About Nectin-4 and Purified
| Nectin-4 | This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011] |
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Images
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Nectin-4 in Human Placenta. Nectin-4 was detected in immersion fixed paraffin-embedded sections of human placenta using 10 µg/mL Goat Anti-Human Nectin-4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2659) overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
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$489.00
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