CD158h Monoclonal / Alexa Fluor 488 / 1127B
CD158h Monoclonal / Alexa Fluor 488 / 1127B
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | FAB8887G-025 (View supplier product page) | |
| Size | 25 Tests | |
| Price | $169.00 | |
| Antigen | CD158h | |
| Clone | 1127B | |
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Alexa Fluor 488 | |
| Target Species | Human | |
| Applications | FC | |
| Description | Human KIR2DS1/CD158h Alexa Fluor® 488-conjugated Antibody |
About CD158h and Alexa Fluor 488
| CD158h | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| Alexa Fluor 488 | Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A. |
Images
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Detection of KIR2DS1/CD158h in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Rabbit Anti-Human KIR2DS1/CD158h Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB8887G) and either (A) Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P) or (B) Mouse Anti-Human KIR2DL1/KIR2DS5 PE-conjugated Monoclonal Antibody (Catalog # FAB1844P). View our protocol for Staining Membrane-associated Proteins. |
Citations
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Reviews & Ratings
Alexa Fluor 488 Excitation and Emission Spectra
$169.00
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