GFR alpha-2 Polyclonal / Unconjugated /

Citations: (1)
Product Details
Supplier R&D Systems
Catalog #: AF613 (View supplier product page)
Size 100 μg
Price $459.00
Antigen GFR alpha-2
Clone
Host Goat
Isotype IgG
Conjugate Unconjugated
Target Species Guinea Pig, Human
Applications WB, IHC, Block, ICC
Description Human GFR alpha-2/GDNF R alpha-2 Antibody
About GFR alpha-2 and Purified
GFR alpha-2 Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Citations
PMID 16516394
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Purified Excitation and Emission Spectra