CHOP Monoclonal / Unconjugated / 671708
CHOP Monoclonal / Unconjugated / 671708
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | MAB7224-SP (View supplier product page) | |
| Size | 25 μg | |
| Price | $149.00 | |
| Antigen | CHOP | |
| Clone | 671708 | |
| Host | Mouse | |
| Isotype | IgG2b | |
| Conjugate | Unconjugated | |
| Target Species | Human, Mouse | |
| Applications | WB, ICC | |
| Description | Human GADD153 Antibody |
About CHOP and Purified
| CHOP | This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010] |
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Images
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GADD153 in Jurkat Human Cell Line. GADD153 was detected in immersion fixed Jurkat human acute T cell leukemia cell line stimulated with PMA and hydrogen peroxide using Mouse Anti-Human GADD153 Monoclonal Antibody (Catalog # MAB7224) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red, upper panel; Catalog # NL007) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Non-adherent Cells. |
Citations
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Purified Excitation and Emission Spectra
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