Flt-3 Monoclonal / Alexa Fluor 750 / 113308

Product Details
Supplier R&D Systems
Catalog #: FAB7681S-100UG (View supplier product page)
Size 100 μg
Price $409.00
Antigen Flt-3
Clone 113308
Host Rat
Isotype IgG2a
Conjugate Alexa Fluor 750
Target Species Mouse
Applications FC
Description Mouse Flt-3/Flk-2 Alexa Fluor® 750-conjugated Antibody
About Flt-3 and Alexa Fluor 750
Flt-3 This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
Alexa Fluor 750 Alexa Fluor™ 750 (AF750, Alexa 750) has an excitation peak at 749 nm and an emission peak at 775 nm, and is spetrally similar to Cy®7 (GE Healthcare), APC-Fire™ 750 (BioLegend), CF®®750 (Biotium), DyLight™ 750 (ThermoFisher Scientific), iFluor® 750 (ATT Bioquest) and iFluor® 790 (ATT Bioquest). Alexa 750 is often used as a tandem fluorophore in flow cytometry or used on its own in fluorescence microscopy, in-vivo fluorescence microscopy or super-resolution microscopy applications.
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Alexa Fluor 750 Excitation and Emission Spectra