FANCD2 Monoclonal / Alexa Fluor 647 / 1290D
FANCD2 Monoclonal / Alexa Fluor 647 / 1290D
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | IC9369R-025 (View supplier product page) | |
| Size | 25 Tests | |
| Price | $159.00 | |
| Antigen | FANCD2 | |
| Clone | 1290D | |
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | Alexa Fluor 647 | |
| Target Species | Human | |
| Applications | ICS | |
| Description | Human FANCD2 Alexa Fluor 647-conjugated Antibody |
About FANCD2 and Alexa Fluor 647
| FANCD2 | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | |
|---|---|---|
| Alexa Fluor 647 | Alexa Fluor™ 647 (AF647, Alexa 647) has an excitation peak at 650 nm and an emission peak at 665 nm, and is spectrally similar to Cy®5 (GE Healthcare), iFluor® 647 (ATT Bioquest), and DyLight™ 650 (Thermo Fisher Scientific). Alexa 647 is commonly used for flow cytometry, microscopy, super-resolution microscopy applications. It is very bright, photostable, and pH insensitive, all of which contribute to sensitive detection while using this dye. |
Images
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Detection of FANCD2 in HeLa Human Cell Line by Flow Cytometry. HeLa human cervical epithelial carcinoma cell line was stained with Rabbit Anti-Human FANCD2 Alexa Fluor® 647-conjugated Monoclonal Antibody (Catalog # IC9369R, filled histogram) or isotype control antibody (Catalog # IC1051R, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules. |
Citations
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Reviews & Ratings
Alexa Fluor 647 Excitation and Emission Spectra
$159.00
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