ErbB2 Monoclonal / Biotin / Hu5
ErbB2 Monoclonal / Biotin / Hu5
Citations:
(2)
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | FAB9589B-100 (View supplier product page) | |
| Size | 100 Tests | |
| Price | $369.00 | |
| Antigen | ErbB2 | |
| Clone | Hu5 | |
| Host | Human | |
| Isotype | IgG1 | |
| Conjugate | Biotin | |
| Target Species | Human | |
| Applications | FC, ICC | |
| Description | ErbB2/Her2 (Research Grade Trastuzumab Biosimilar) Biotinylated Antibody |
About ErbB2 and Biotin
| ErbB2 | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] |
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Images
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Detection of ErbB2/Her2 in MCF-7 human cell line by Flow Cytometry. MCF-7 human cell line was stained with Biotinylated Human Anti-Human ErbB2/Her2 (Trastuzumab) Monoclonal Antibody (Catalog # FAB9589B, filled histogram) or irrelevant antibody (open histogram) followed by APC-conjugated Streptavidin (Catalog # F0050). View our protocol for Staining Membrane-associated Proteins. |
Citations
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Reviews & Ratings
Biotin Excitation and Emission Spectra
$369.00
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