CD324 Monoclonal / PE / 180224
CD324 Monoclonal / PE / 180224
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | FAB18381P-100 (View supplier product page) | |
| Size | 100 Tests | |
| Price | $409.00 | |
| Antigen | CD324 | |
| Clone | 180224 | |
| Host | Mouse | |
| Isotype | IgG2b | |
| Conjugate | PE | |
| Target Species | Human | |
| Applications | FC | |
| Description | Human E-Cadherin PE-conjugated Antibody |
About CD324 and PE
| CD324 | This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015] | |
|---|---|---|
| PE | Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts. |
Images
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Detection of E-Cadherin in MCF-7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line was stained with Mouse Anti-Human E-Cadherin PE-conjugated Monoclonal Antibody (Catalog # FAB18381P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). Cells were stained in a buffer containing Ca2+ and Mg2+. View our protocol for Staining Membrane-associated Proteins. |
Citations
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Reviews & Ratings
PE Excitation and Emission Spectra
$409.00
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