CXCL11 Polyclonal / Unconjugated /
CXCL11 Polyclonal / Unconjugated /
Citations:
(1)
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | AF260 (View supplier product page) | |
| Size | 100 μg | |
| Price | $469.00 | |
| Antigen | CXCL11 | |
| Clone | ||
| Host | Goat | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Human, Mouse | |
| Applications | WB, Block/Neutralize, IHC-Fr | |
| Description | Human CXCL11/I-TAC Antibody |
About CXCL11 and Purified
| CXCL11 | Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] |
|---|
Images
|
Chemotaxis Induced by CXCL11/I-TAC and Neutralization by Human CXCL11/I-TAC Antibody. Recombinant Human CXCL11/I-TAC (Catalog # 672-IT) chemoattracts the BaF3 mouse pro-B cell line transfected with human CXCR3 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Human CXCL11/I-TAC (0.05 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human CXCL11/I-TAC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF260). The ND50 is typically 0.5-1.5 µg/mL. |
Citations
| PMID 19265171 | ||
|---|---|---|
| Additional Sources |
|
Reviews & Ratings
Purified Excitation and Emission Spectra
$469.00
Supplier Page
Supplier Page
