RANTES Monoclonal / Unconjugated / 53433

Product Details
Supplier R&D Systems
Catalog #: MAB4781-500 (View supplier product page)
Size 500 μg
Price $1,529.00
Antigen RANTES
Clone 53433
Host Rat
Isotype IgG1
Conjugate Unconjugated
Target Species Human, Mouse
Applications ELISA
Description Mouse CCL5/RANTES Antibody
About RANTES and Purified
RANTES This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
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Purified Excitation and Emission Spectra