RANTES Polyclonal / Unconjugated /
RANTES Polyclonal / Unconjugated /
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | AF3819 (View supplier product page) | |
| Size | 100 μg | |
| Price | $459.00 | |
| Antigen | RANTES | |
| Clone | ||
| Host | Sheep | |
| Isotype | IgG | |
| Conjugate | Unconjugated | |
| Target Species | Feline | |
| Applications | WB, ELISA, Block/Neutralize | |
| Description | Feline CCL5/RANTES Antibody |
About RANTES and Purified
| RANTES | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
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Images
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Chemotaxis Induced by CCL5/RANTES and Neutral-ization by Feline CCL5/ RANTES Antibody. Recombinant Feline CCL5/ RANTES (Catalog # 3819-FR) chemoattracts the BaF3 mouse pro-B cell line transfected with human CCR5 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Feline CCL5/ RANTES (80 ng/mL) is neutral-ized (green line) by increasing concen-trations of Sheep Anti-Feline CCL5/RANTES Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3819). The ND50 is typically 0.5-2.5 µg/mL. |
Citations
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Reviews & Ratings
Purified Excitation and Emission Spectra
$459.00
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