CBL Polyclonal / Unconjugated /
CBL Polyclonal / Unconjugated /
Product Details
Supplier | R&D Systems | |
---|---|---|
Catalog #: | AF5998-SP (View supplier product page) | |
Size | 25 μg | |
Price | $149.00 | |
Antigen | CBL | |
Clone | ||
Host | Goat | |
Isotype | IgG | |
Conjugate | Unconjugated | |
Target Species | Human, Mouse | |
Applications | WB | |
Description | Human/Mouse CBL Antibody |
About CBL and Purified
CBL | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016] |
---|
Images
![]() |
Detection of Human CBL by Western Blot. Western blot shows lysates of MCF-7 human breast cancer cell line, K562 human chronic myelogenous leukemia cell line, and Raji human Burkitt's lymphoma cell line. PVDF Membrane was probed with 0.5 µg/mL of Goat Anti-Human/Mouse CBL Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5998) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for CBL at approximately 120 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1. |
Citations
Reviews & Ratings
Purified Excitation and Emission Spectra
$149.00
Supplier Page
Supplier Page