BMP-7 Monoclonal / Unconjugated / 164313
BMP-7 Monoclonal / Unconjugated / 164313
Product Details
| Supplier | R&D Systems | |
|---|---|---|
| Catalog #: | MAB3542-SP (View supplier product page) | |
| Size | 25 μg | |
| Price | $149.00 | |
| Antigen | BMP-7 | |
| Clone | 164313 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | Unconjugated | |
| Target Species | Human | |
| Applications | IHC, ELISA, Block/Neutralize, WB | |
| Description | Human BMP-7 Antibody |
About BMP-7 and Purified
| BMP-7 | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016] |
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Images
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Alkaline Phosphatase Production Induced by BMP-7 and Neutralization by Human BMP-7 Antibody. Recombinant Human BMP-7 (Catalog # 354-BP) induces alkaline phosphatase production in the the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline phosphatase production elicited by Recombinant Human BMP-7 (1 µg/mL) is neutralized (green line) by increasing concentrations of Human BMP-7 Monoclonal Antibody (Catalog # MAB3542). The ND50 is typically 4-12 µg/mL in the presence of L-ascorbic acid (50 µg/mL). |
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BMP-7 in Human Prostate Cancer Tissue. BMP-7 was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using 25 µg/mL Human BMP-7 Monoclonal Antibody (Catalog # MAB3542) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
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BMP-7 in Human Prostate. BMP-7 was detected in immersion fixed paraffin-embedded sections of human prostate using Human BMP-7 Monoclonal Antibody (Catalog # MAB3542) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
Citations
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