FluoroFinder

	Supplier	R&D Systems
	Catalog #:	AF507-SP (View supplier product page)
	Size	25 μg
	Price	$149.00
	Antigen	BMP-6
	Clone
	Host	Goat
	Isotype	IgG
	Conjugate	Unconjugated
	Target Species	Human, Mouse
	Applications	WB, IHC, Block/Neutralize
	Description	Human BMP-6 Antibody

	BMP-6	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]

		Alkaline Phosphatase Production Induced by BMP-6 and Neutralization by Human BMP-6 Antibody. Recombinant Human BMP-6 (Catalog # 507-BP) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline phosphatase production elicited by Recombinant Human BMP-6 (0.15 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human BMP-6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF507). The ND₅₀ is typically 0.75-3.75 µg/ml in the presence of L-ascorbic acide (50 µg/mL).
		BMP-6 in Human Lung. BMP-6 was detected in immersion fixed paraffin-embedded sections of human lung using Goat Anti-Human BMP-6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF507) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to smooth muscle in vasculature. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.