Syntrophin alpha 1 Monoclonal / DyLight 405 / 10

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-22587V (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen Syntrophin alpha 1
Clone 10
Host Mouse
Isotype IgG2b κ
Conjugate DyLight 405
Target Species Human
Applications WB, ELISA, ICC/IF
Description Syntrophin alpha 1 Antibody (1E1) [DyLight 405]
About Syntrophin alpha 1 and DyLight 405
Syntrophin alpha 1 Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]
DyLight 405 DyLight™ 405 has an excitation peak at 400 nm and an emission peak at 420 nm and is spectrally similar to Alexa Fluor™ 405 and Cascade Blue. DyLight™ 405 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 405 Excitation and Emission Spectra