CD33 Monoclonal / Alexa Fluor 405 / WM53

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-34511AF405 (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen CD33
Clone WM53
Host Mouse
Isotype IgG1 κ
Conjugate Alexa Fluor 405
Target Species Human
Applications FC, ELISA, ICC/IF, IHC-Fr, IHC
Description Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immuno-receptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
About CD33 and Alexa Fluor 405
CD33 Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
Citations
Additional
Sources
Reviews & Ratings
Submit a Review

Alexa Fluor 405 Excitation and Emission Spectra