SHBG Monoclonal / Biotin / SHBG/245

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-48007B (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen SHBG
Clone SHBG/245
Host Mouse
Isotype IgG1
Conjugate Biotin
Target Species Human
Applications IHC-P, IHC
Description Recognizes a protein of 45kDa, identified as SHBG. It functions as an androgen transport protein, but may also be involved in receptor-mediated processes. Each dimer binds one molecule of steroid. It is specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
About SHBG and Biotin
SHBG This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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Biotin Excitation and Emission Spectra