RPE65 Monoclonal / DyLight 488 / 401.8B11.3D9

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-355G (View supplier product page)
Size 0.2 ml
Price $599.00
Antigen RPE65
Clone 401.8B11.3D9
Host Mouse
Isotype IgG1 κ
Conjugate DyLight 488
Target Species Bovine, Canine, Chicken, Human, Mouse, Porcine, Rat, Xenopus
Applications WB, FC, ICC/IF, IHC-P, IHC-Fr, IHC
Description Mouse RPE65 antibody reacts with Human, Mouse, Rat, Porcine, Bovine, Canine, Chicken, Xenopus [DyLight 488]
About RPE65 and DyLight 488
RPE65 The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017]
DyLight 488 DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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DyLight 488 Excitation and Emission Spectra