NKX2.2 Monoclonal / DyLight 488 / SPM564

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP2-34799G (View supplier product page)
Size 0.1 ml
Price $519.00
Antigen NKX2.2
Clone SPM564
Host Mouse
Isotype IgG2b κ
Conjugate DyLight 488
Target Species Chicken, Human, Mouse, Rat
Applications WB, FC, ELISA, ICC/IF, IP, IHC-P, IHC-Fr, IHC
Description Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
About NKX2.2 and DyLight 488
NKX2.2 The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]
DyLight 488 DyLight™ 488 has an excitation peak at 493 nm and an emission peak at 518 nm and is spectrally similar to Alexa Fluor™ 488, fluorescein and FITC. DyLight™ 488 is most commonly used in flow cytometery, and fluorescence microscopy applications.
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DyLight 488 Excitation and Emission Spectra