MUC-1 Monoclonal / Alexa Fluor 405 / PR 4D1

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB100-2689AF405 (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen MUC-1
Clone PR 4D1
Host Mouse
Isotype IgG1
Conjugate Alexa Fluor 405
Target Species Human
Applications IHC, IHC-Fr
Description Epithelia (colonic) Antibody (PR 4D1) [Alexa Fluor 405]
About MUC-1 and Alexa Fluor 405
MUC-1 This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Alexa Fluor 405 Alexa Fluor™ 405 (AF405, Alexa 405) has an excitation peak at 401 nm and an emission peak at 421 nm and is similar in size, brightness and application to ABflo 405® (ABclonal) and Cascade Blue® (ThermoFisher Scientific). Alexa 405 is commonly used in flow cytometery and fluorescence microscopy applications.
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Alexa Fluor 405 Excitation and Emission Spectra