MUC-1 Monoclonal / DyLight 680 / M9E7

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NB120-8322FR (View supplier product page)
Size 200 μl
Price $399.00
Antigen MUC-1
Clone M9E7
Host Mouse
Isotype IgG
Conjugate DyLight 680
Target Species Human
Applications ELISA, IHC, IHC-Fr
Description Reacts with VNTR5 and VNTR20 recombinant unglycosylated fragments of MUC1 protein and underglycosylated MUC1 Does not recognize natural MUC1 protein.No cross reactivity with egg white avidin. Affinity = > 1.0 x108
About MUC-1 and DyLight 680
MUC-1 This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
DyLight 680 DyLight™ 680 has an excitation peak at 692 nm and an emission peak at 712 nm, and is spectrally similar to Alexa Fluor™ 680 and Cy5.5. DyLight™ 680 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 680 Excitation and Emission Spectra