MUC-1 Polyclonal / DyLight 405 /

Product Details
Supplier Novus Biologicals, a Bio-Techne brand
Catalog #: NBP1-60046V (View supplier product page)
Size 0.1 ml
Price $499.00
Antigen MUC-1
Clone
Host Rabbit
Isotype IgG
Conjugate DyLight 405
Target Species Bovine, Equine, Goat, Guinea Pig, Human, Mouse, Porcine, Rabbit, Rat
Applications WB, IHC, ICC/IF, IHC-P
Description The immunogen for this antibody has 100% homology to human MUC1 isoforms S2, E2, 9, F, T10, 5, Y, Y-LSP, 8, 4, 3, 2, 1 and J13.
About MUC-1 and DyLight 405
MUC-1 This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
DyLight 405 DyLight™ 405 has an excitation peak at 400 nm and an emission peak at 420 nm and is spectrally similar to Alexa Fluor™ 405 and Cascade Blue. DyLight™ 405 is most commonly used in flow cytometery and fluorescence microscopy applications.
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DyLight 405 Excitation and Emission Spectra