SHIP1 Monoclonal / Unconjugated / PTY15

Product Details
Supplier GeneTex
Catalog #: GTX18708 (View supplier product page)
Size 100 μg
Price $289.00
Antigen SHIP1
Clone PTY15
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Target Species Human
Applications ELISA, ICC/IF, WB
Description The Anti-SHP1 antibody [PTY15] from GeneTex is a Mouse Monoclonal antibody to SHP1. The Anti-SHP1 antibody [PTY15] Recognizes Human. The Anti-SHP1 antibody [PTY15] has been validated for the following Applications: ELISA, ICC/IF, WB.
About SHIP1 and Purified
SHIP1 This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]
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Purified Excitation and Emission Spectra