FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-117-694 (View supplier product page)
	Size	100 tests in 200 µL
	Price	$330.00
	Antigen	CD279 (PD1)
	Clone	PD1.3.1.3
	Host	Mouse
	Isotype	IgG2b κ
	Conjugate	APC
	Target Species	Human
	Applications	MICS (MACSima Imaging Cyclic Staining), FC, IF, IHC, Functional
	Description	PD1.3.1.3 recognizes human CD279, also known as programmed death-1 (PD-1). It is a 55 kDa transmembran protein belonging to the CD28/CTLA-4 family. It is expressed on T cells, B cells, NK cells, and activated myeloid cells. CD279 is not expressed on naive T cells but induced after activation and expressed on late, differentiated T cells. The ligands PD-L1 (B7-H1; CD274) and PD-L2 (B7-DC; CD273) belong to the B7 immunglobulin superfamily. PD1 and its ligands mediate inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology. Clone PD.1.3.1.3 has been used to block the binding of both ligands.

	CD279 (PD1)	Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

$330.00
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CD279 (PD1) / APC / PD1.3.1.3