CD38 / APC / IB6

Citations: (1)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-113-986 (View supplier product page)
Size 30 tests in 60 µL
Price $145.00
Antigen CD38
Clone IB6
Host Mouse
Isotype IgG2a κ
Conjugate APC
Target Species Human
Applications MICS (MACSima Imaging Cyclic Staining), FC, IF, IHC
Description Clone IB6 recognizes the human CD38 antigen, a single-chain type II trans­membrane glycoprotein with enzymatic activity. It is present on the majority of hematopoietic cells, prevalent during early differentiation and activation processes. Terminally differentiated B cells (plasma cells) express CD38 brightly. Furthermore, CD38 is constitutively expressed in several tissues, for example brain, muscle, and kidney.
About CD38 and APC
CD38 The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
APC Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Citations
PMID 20372106
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APC Excitation and Emission Spectra