ABCG2 / Unconjugated /

Citations: (2)
Product Details
Supplier Enzo Life Sciences
Catalog #: ALX-801-029 (View supplier product page)
Size 125 μg
Price $462.00
Antigen ABCG2
Clone
Host Mouse
Isotype IgG2a
Conjugate Unconjugated
Target Species Human
Applications IHC
Description Unconjugated Breast cancer resistance protein Mouse antibody; detects Human
About ABCG2 and Purified
ABCG2 The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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Purified Excitation and Emission Spectra