Ly-49A Monoclonal / PE / REA1018
Ly-49A Monoclonal / PE / REA1018
Citations:
(3)
Product Details
| Supplier | Miltenyi Biotec | |
|---|---|---|
| Catalog #: | 130-117-070 (View supplier product page) | |
| Size | 150 µg in 1 mL | |
| Price | $240.00 | |
| Antigen | Ly-49A | |
| Clone | REA1018 | |
| Host | Human | |
| Isotype | IgG1 | |
| Conjugate | PE | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | Clone REA1018 recognizes th mouse Ly-49A antigen, an inhibitory cell surface receptor belonging to the Ly-49 receptor family. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK-T cells. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49A interacts strongly with MHC class Ia molecules such as H-2Dd, H-2Dk, and weakly with H-2Db. An inhibitory signal is delivered by Ly-49A engagement via the phosphorylation of immunoreceptor tyrosine based inhibition motif (ITIM) and recruitment of phosphatases SHP-1 and SHP-2. Recognition of cognate ligand bearing cells leads to inhibition of cytotoxic killing of cells by NK cells. | Additional information: Clone REA1018 displays negligible binding to Fc receptors. |
Citations
| PMID 10457220 | ||
|---|---|---|
| PMID 11120818 | ||
| PMID 11714759 | ||
| Additional Sources |
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Reviews & Ratings
PE Excitation and Emission Spectra
$240.00
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